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Advances in chemistry, biology, biophysics and engineering have increased efficiency in screening compounds for drug-like activity. We will discuss screening methods for hit identification and lead optimization, including the interaction of medicinal chemistry with the screening process, as well as new approaches to biological models for drug discovery. Topics include: assay and screening technologies, liquid handling, automation, assay miniaturization for screening in ultra-HTS formats, compound handling and management, readers and detection technologies for high throughput and for high content screening, data analysis, assay transfer from assay development to HTS, cell culture for cell-based HTS and computational approaches and high-density high throughput assay formats for fast and comprehensive ADMET guidance in hit-to-lead chemistry.

Course Number: BIOL-40133
Credit: 2.00 unit(s)