Advances in biology, chemistry, biophysics and engineering have resulted in a vast number of potential disease-relevant drug targets and an increased efficiency in screening compounds for drug-like activity. Students will learn both the conceptual and current methodology being utilized in the identification and validation of new targets for drug intervention. This course will explore screening methods for hit identification and lead optimization as well as new approaches to biological models for drug discovery.
The particular topics to be discussed include: the concepts of target identification and validation; in vitro and in vivo techniques; how this approach is driving present drug discovery efforts; pharmaceutical companies’ new potential pharmacological targets; historical prospective of the evolution of TI/TV efforts and the paradigm shift to gene-derived targets.
Learning Outcomes
By the of this course, students will be able to:
- Understand the principles of target identification and validation and strategies used in target and drug discovery.
- Explain the various drug target classes and explain specific techniques used for target identification and validation
- Understand the principles of target screening strategies, assays and approaches used in lead identification and optimization during preclinical development of drugs
- Appreciate the evolution of target identification from past to present and future strategies
Course Number: BIOL-40331
Credit: 2.00 unit(s)
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4/8/2024 - 5/20/2024
$625
Online
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CLASS TYPE:
Online Asynchronous.
This course is entirely web-based and to be completed asynchronously between the published course start and end dates. Synchronous attendance is NOT required.
You will have access to your online course on the published start date OR 1 business day after your enrollment is confirmed if you enroll on or after the published start date.
INSTRUCTOR:
Vijapurkar, Ulka
Dr. Vijapurkar has a Ph.D in Pharmacology from the University of Iowa. She did her post-doctoral fellowship in cancer biology and has over 10 years of experience in the biotech/pharmaceutical industry where she worked on project teams in discovery research, target identification/validation to early clinical development. She currently teaches physiology and pharmacology courses at UCSD Biological sciences and school of Pharmacy.
She enjoys mentoring and motivating students to develop a genuine interest in the subject matter, become critical thinkers and gain the scientific knowledge that has implications for the advancement of their careers and beyond.
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POLICIES:
No refunds after: 4/15/2024.
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4/8/2024 - 5/20/2024
extensioncanvas.ucsd.edu
You will have access to your course materials on the published start date OR 1 business day after your enrollment is confirmed if you enroll on or after the published start date.
There are no sections of this course currently scheduled. Please contact the Science & Technology department at 858-534-3229 or unex-sciencetech@ucsd.edu for information about when this course will be offered again.